Author
Centre National de la Recherche ScientifiqueORCID 0000-0003-0477-2158Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Myriam Zheng, Fanny Pouyet, Samuel O’Donnell…·Benoı̂t Palancade
The paper identifies mutational signatures caused by DNA:RNA hybrids in yeast genomes, revealing a common mechanism of genetic instability through repair pathways.
Umberto Aiello, Kevin R. Roy, Lars Michael Steinmetz
The paper develops a CRISPR-based platform to scan mutations in essential genes, applying it to Nrd1 to identify critical residues in its CTD-interacting domain.
Heta Patel, Stefano Coppola, Wim Pomp…·Tineke Laura Lenstra
The paper shows DNA supercoiling inhibits transcriptional bursting of neighboring genes in yeast, differing from bacterial mechanisms.
Umberto Aiello, Drice Challal, Griselda Wentzinger…·Domenico Libri
The paper shows Sen1 resolves transcription-driven conflicts and maintains genomic stability by terminating non-coding transcription and resolving R-loops.
Juanjuan Xie, Umberto Aiello, Yves Clément…·Odil Porrúa
The paper investigates RNAPIII transcription termination in budding yeast, showing T-tracts are necessary but not sufficient, and secondary structures and Sen1 helicase are important for termination.