Michalis Averof

foxQ2 marks fast-acting interneurons including dopaminergic neurons of mushroom bodies and central complex in the beetle T. castaneum

Genome-wide chromatin reset at the onset of leg regeneration in pancrustaceans

The paper investigates chromatin state reorganization during leg regeneration in pancrustaceans, finding a conserved sequence of chromatin resetting and pioneer factor activation across species.

Genome-wide discovery of cis-regulatory elements in a large genome

The paper develops resources to identify cis-regulatory elements in the Parhyale hawaiensis genome using ATAC-seq and sequence conservation analysis.

Targeting the cell membrane in established and emerging model organisms

The paper develops a toolkit of membrane-localising tags tested across ten animal species to identify effective signals for targeting proteins to the plasma membrane.

Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs

The paper presents a method for long-term live imaging and cell tracking during crustacean leg regeneration, enabling detailed analysis of cell fates and lineages.

Regenerated crustacean limbs are precise replicas

The paper shows that regenerated crustacean legs in Parhyale precisely replicate the microanatomy, sensory function, and transcriptional profiles of uninjured legs.

Distinct gene expression dynamics in developing and regenerating limbs

This study compares gene expression dynamics during leg development and regeneration in Parhyale hawaiensis, finding distinct temporal patterns despite shared gene sets.

Tracking cell lineages in 3D by incremental deep learning

ELEPHANT enables accurate 3D cell lineage tracking in crustacean leg regeneration using an incremental deep learning approach with minimal user effort.

CeLaVi: An Interactive Cell Lineage Visualisation Tool

CeLaVi is a web-based tool for visualizing and interacting with cell lineages, integrating spatial distribution and cell properties.

Is it possible to reconstruct an accurate cell lineage using CRISPR recorders?

This study uses simulations to evaluate the accuracy of CRISPR-based lineage reconstruction under various biological and technical conditions.

Clonal analysis by tunable CRISPR-mediated excision

The paper introduces Valcyrie, a CRISPR-based method for tunable clonal marking in Tribolium castaneum, enabling controlled clone induction frequency.

Repeated co-option of a conserved gene regulatory module underpins the evolution of the crustacean carapace, insect wings and other flat outgrowths

The paper identifies a conserved gene regulatory module co-opted multiple times for the evolution of flat structures in arthropods.

The genome of the crustacean Parhyale hawaiensis: a model for animal development, regeneration, immunity and lignocellulose digestion

The paper sequences and annotates the genome of Parhyale hawaiensis, identifying key genes for development, immunity, and lignocellulose digestion, providing a resource for comparative studies.