Author

Adam J. Granger

Broad InstituteORCID 0000-0002-3953-6764Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Bernardo Luis SabatiniiD· 3 shared Andrea F Zanello· 2 shared Arpiar B. SaundersiD· 2 shared Beth StevensiD· 2 shared Brian Wai Chow· 2 shared Chenghua GuiD· 2 shared Karina BistrongiD· 2 shared Keiramarie RobertsoniD· 2 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Bernardo Luis SabatiniORCID

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4 papers

Recent·Most cited

iAstrocytes model cytokine influences on complement expression and neuronal network synchronization.

Nader Morshed, Matthew Demers, Ana Gonzalez‐Ramos, Henna Jäntti, Jordan L. Doman, Sean D'Souza, Letian Li, Adam J. Granger, Matthew B. Johnson, Beth Stevens

The paper develops a method to generate functional induced astrocytes (iAstrocytes) from human pluripotent stem cells and shows their role in promoting synchronized neuronal network activity.

bioRxiv · Jun 5, 2026 · PreprintNeuroscience

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

Bryan J. Song, Yang Ge, Ally A. Nicolella, Min Jee Kwon, Bart Lodder, Kevin Bonanno, Antia Valle-Tojeiro, Nolan D. Hartley, Kira Perzel Mandell, John Adeleye, Deeksha Misri, Chuhan Geng, Sahana Natarajan, Inès Picard, Nate Shepard, , Morgan Sheng

This study investigates Akap11 mutant mice to explore the neurobiological effects of AKAP11 loss, finding increased PKA activity and transcriptomic changes linked to schizophrenia and bipolar disorder.

Nature Communications · Nov 28, 2025Peer-reviewedNeuroscience

Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region specific manner

Adam J. Granger, Wengang Wang, Keiramarie Robertson, Mahmoud El-Rifai, Andrea F Zanello, Karina Bistrong, Arpiar B. Saunders, Brian Wai Chow, Vicente Nuñez, Miguel Turrero Garcίa, Corey C. Harwell, Chenghua Gu, Bernardo Luis Sabatini

The paper identifies that cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region specific manner, revealing heterogeneity in their function and connectivity.

eLife · Jul 2, 2020Peer-reviewedNeuroscience

Target-specific co-transmission of acetylcholine and GABA from a subset of cortical VIP+ interneurons

Adam J. Granger, Wengang Wang, Keiramarie Robertson, Mahmoud El-Rifai, Andrea F Zanello, Karina Bistrong, Arpiar B. Saunders, Brian Wai Chow, Vicente Nuñez, Chenghua Gu, Bernardo Luis Sabatini

The paper identifies VIP/ChAT interneurons as a local source of cortical ACh and shows they co-transmit ACh and GABA to specific post-synaptic targets.

bioRxiv · Nov 12, 2018 · PreprintNeuroscience