Simon Ming‐Yuen Lee

Multimodal AI Decodes Extreme Environment Functional Dark Matter Beyond Homology

The paper develops ACCESS, a multimodal graph neural network to annotate functional dark matter proteins from extreme environments beyond homology-based methods.

Crocin inhibited amyloid-beta (Aβ) generation via promoting non-amyloidogenic APP processing and suppressed ER stress UPR signaling in N2a/APP cells

Complete chloroplast genomes of 14 mangroves: phylogenetic and genomic comparative analyses

The paper reports complete chloroplast genomes of 14 mangrove species and performs phylogenetic and genomic comparative analyses to understand their evolutionary relationships.

SMARTer single cell total RNA sequencing

The paper introduces a novel single cell strand-specific total RNA sequencing method that overcomes limitations of existing techniques and detects more genes, including non-polyadenylated ones.

Dynamic chromosome rearrangements of the white-spotted bamboo shark shed light on cartilaginous fish diversification mechanisms

The paper reports the chromosome-level genome of the white-spotted bamboo shark and shows chromosome rearrangements contribute to phenotypic diversity in cartilaginous fishes.

Sequencing of Panax notoginseng genome reveals genes involved in disease resistance and ginsenoside biosynthesis

The paper reports the first de novo genome of Panax notoginseng, identifies gene family contractions and expansions related to disease resistance and ABC transporters, and maps key genes in the ginsenoside biosynthesis pathway.

Universal target-enrichment baits for anthozoan (Cnidaria) phylogenomics: New approaches to long-standing problems

The paper designs and tests RNA baits to capture phylogenetically informative loci in anthozoans, successfully resolving evolutionary relationships across multiple taxa.