Disruption of ribosome dynamics and mRNA homeostasis triggers a cascading imbalance in protein synthesis in models of Amyotrophic Lateral Sclerosis
Fabio Lauria, Federica Maniscalco, Cecilia Perrucci, Marta Marchioretto, Ilaria Bruno, Gabriele Tomè, Federica Cella, Emma Busarello, Martina Sevegnani, Lorenzo Lunelli, Luisa Donini, Toma Tebaldi, Michael H. Antoni, Daniele Pollini, Daniele Peroni, , Gabriella Viero
This study investigates how TDP-43 dysregulation disrupts protein synthesis in ALS models by altering ribosome dynamics and mRNA homeostasis, revealing a conserved mechanism across in vitro and in vivo systems.
bioRxiv · May 15, 2025 · PreprintMolecular Biology