Author

Martina Sevegnani

University of Trento

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Assay:Ribo-seq· 1

Frequent Co-Authors

Cecilia PerrucciiD· 2 shared Fabio LauriaiD· 2 shared G. Giacomo ConsaleziD· 2 shared Gabriele TomèiD· 2 shared Gabriella VieroiD· 2 shared Giovanni PiccoliiD· 2 shared Ilaria BrunoiD· 2 shared Laura CrociiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Cecilia PerrucciORCID

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4 papers

Recent·Most cited

LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics

Giulia Tombesi, Shiva N. Kompella, Giulia Favetta, Chuyu Chen, Marta Ornaghi, Yibo Zhao, Ester Morosin, Martina Sevegnani, Adriano Lama, Antonella Marte, Ilaria Battisti, Lucia Iannotta, Nicoletta Plotegher, Laura Civiero, Franco Onofri, , Elisa Greggio

This study shows that LRRK2 regulates synaptic function by modulating actin cytoskeletal dynamics through BDNF signaling in neurons.

eLife · Aug 6, 2026Peer-reviewedNeuroscience

Empowering multiplexed ultra-throughout ribosome profiling with RiboWich

Ilaria Bruno, Cecilia Perrucci, Gabriele Tomè, Giorgia Susin, Stefania Mazzalai, Martina Sevegnani, Alessia Del Piano, Luisa Donini, Manuela Basso, Massimiliano Clamer, Elena Perenthaler, Fabio Lauria, Gabriella Viero

RiboWich improves ribosome profiling by eliminating ribosome purification and enabling high-throughput, low-input translatome analysis.

bioRxiv · Oct 17, 2025 · PreprintMolecular Biology

Disruption of ribosome dynamics and mRNA homeostasis triggers a cascading imbalance in protein synthesis in models of Amyotrophic Lateral Sclerosis

Fabio Lauria, Federica Maniscalco, Cecilia Perrucci, Marta Marchioretto, Ilaria Bruno, Gabriele Tomè, Federica Cella, Emma Busarello, Martina Sevegnani, Lorenzo Lunelli, Luisa Donini, Toma Tebaldi, Michael H. Antoni, Daniele Pollini, Daniele Peroni, , Gabriella Viero

This study investigates how TDP-43 dysregulation disrupts protein synthesis in ALS models by altering ribosome dynamics and mRNA homeostasis, revealing a conserved mechanism across in vitro and in vivo systems.

bioRxiv · May 15, 2025 · PreprintMolecular Biology

Dopamine neuron dysfunction and loss in the PrknR275W mouse model of Juvenile Parkinsonism

Maria Regoni, Letizia Zanetti, Martina Sevegnani, Chiara Domenicale, Stefano Magnabosco, Jyoti C. Patel, Megan K. Fernandes, Ryan M. Feeley, Elena Monzani, Cecilia Mini, Stefano Comai, Laura Cherchi, Danilo De Gregorio, Isabella Soliman, Fabio Ruto, , Jenny Sassone

This study creates a PrknR275W mouse model of ARJP, showing early dopamine neuron dysfunction, age-dependent loss, and motor impairment, recapitulating key features of juvenile Parkinsonism.

Brain · Oct 1, 2024Peer-reviewedNeuroscience