This study identifies the Man-PTS as a receptor for Angicin in streptococci and defines structural features associated with its antimicrobial activity.

bioRxiv · Jun 4, 2026 · PreprintMicrobiology

Provirus deletion from Haloferax volcanii affects motility, stress resistance and CRISPR RNA expression

Nadia Di Cianni, Simon Bolsinger, Jutta Brendel, Monika Raabe, Sabine König, Laura Mitchell, Thorsten Bischler, Tom Gräfenhan, Clarissa Read, Susanne Erdmann, Thorsten Allers, Paul Walther, Henning Urlaub, Mike Dyall‐Smith, Friedhelm Pfeiffer, Anita Marchfelder

The paper deletes four proviruses in Haloferax volcanii and finds increased motility, stress resistance, and altered CRISPR RNA expression.

microLife · Jan 1, 2025Peer-reviewedMolecular Biology

Poxviruses induce a nuclear environment in the cytoplasm to promote viral replication

Pia Veratti, Emanuel Wyler, Clarissa Read, Myriam Scherer, Tan Jiang, Paul Walther, Stephanie Wider, Daniel Weidl, Florian Full

This study investigates the cellular response to poxvirus infection, showing that MVA activates innate immune genes, while Camelpoxvirus activates NF-kB signaling, and poxviruses induce nuclear remodeling by transporting nuclear proteins into viral factories.

bioRxiv · Nov 21, 2024 · PreprintMicrobiology

ARF1 prevents aberrant type I IFN induction by regulating STING activation and recycling

Maximilian Hirschenberger, Alice Lepelley, Ulrich Rupp, Susanne Klute, Victoria Hunszinger, Lennart Koepke, Veronika Merold, Blaise Didry‐Barca, Fanny Wondany, Tim Bergner, Sebastian Wiese, Stefano Volpi, Marco Gattorno, Riccardo Papa, Sally Ann Lynch, , Konstantin M. J. Sparrer

This study identifies ARF1 as a negative regulator of cGAS-STING signaling, showing it prevents type I IFN induction by regulating STING activation and recycling.

medRxiv · Apr 28, 2023 · PreprintGenetic & Genomic Medicine