Christina M. Lill

GWAS on short tandem repeats identifies novel genetic mechanisms in Alzheimer's disease

This study conducts GWAS on short tandem repeats (STRs) to identify novel genetic mechanisms in Alzheimer's disease using data from ~330,000 individuals.

Biological age acceleration measured by DunedinPACE associates most consistently with cognitive decline in elderly individuals

This study finds that DunedinPACE, an epigenetic clock, most consistently associates with cognitive decline in older adults compared to other DNAm clocks and telomere length.

Identification of lncRNAs differentially expressed in Alzheimer's disease brains using RNA sequencing

The paper identifies differentially expressed lncRNAs in Alzheimer's disease brains using RNA-seq data from multiple studies and brain regions.

Peripheral immune profiles in individuals at genetic risk for amyotrophic lateral sclerosis and Alzheimer's disease

The paper examines immune cell profiles in individuals with genetic risk for ALS and AD, finding nominally significant associations but no significant associations after FDR correction.

Immune cell distributions in the blood of healthy individuals at high genetic risk of Parkinson's disease

The paper examines immune cell distributions in healthy individuals at high genetic risk of Parkinson's disease and finds no significant associations between polygenic risk scores and immune cell subtypes, though some nominally significant associations were observed.

Blood-based multivariate methylation risk score for cognitive impairment and dementia

The paper develops a multivariate methylation risk score using blood DNA methylation data to predict dementia risk and cognitive impairment in Alzheimer's and Parkinson's disease cohorts.

Genome-wide association study reveals different T cell distributions in peripheral blood of healthy individuals at high genetic risk of type 1 diabetes and long COVID

This paper conducts a GWAS to identify genetic loci associated with immune cell distributions in healthy individuals and links these to type 1 diabetes and long COVID risk.

Genome-wide QTL mapping across three tissues highlights several Alzheimer's and Parkinson's disease loci potentially acting via DNA methylation

The paper maps DNA methylation quantitative trait loci (meQTL) in three tissues and uses Mendelian randomization to link DNAm to Alzheimer's and Parkinson's disease risk.

Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease

This study identifies four novel DNA methylation loci in the entorhinal cortex associated with Alzheimer's disease and finds significant epigenetic age acceleration in patients.

A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples

The paper correlates DNA methylation patterns between buccal and brain samples to identify CpG sites with significant methylation correlations and genetic determinants.

Common signatures of differential microRNA expression in Parkinson's and Alzheimer's disease brains

The paper assesses differential microRNA expression in Parkinson's and Alzheimer's disease brains, identifying shared miRNAs with potential pathogenic roles.

Differential microRNA expression analyses across two brain regions in Alzheimer's disease

The paper identifies differentially expressed miRNAs in two brain regions of Alzheimer's patients using qPCR and RNA-seq, highlighting potential targets involved in AD pathogenesis.

Genome-wide association study of Alzheimer's disease brain imaging biomarkers and neuropsychological phenotypes in the EMIF-AD Multimodal Biomarker Discovery dataset

This study performs GWAS on quantitative AD biomarkers and cognitive traits, identifying new loci associated with memory performance and cognitive decline.

TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels

The paper conducts GWAS on CSF Alzheimer's disease biomarkers, identifying genetic associations with NF-L, YKL-40, and Ng levels.

The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility

The paper reports a detailed genetic and genomic map of multiple sclerosis, identifying susceptibility genes in peripheral immune cells and brain-resident microglia.

Risky behaviors and Parkinson’s disease: A Mendelian randomization study in up to 1 million study participants

This study uses Mendelian randomization to investigate causal links between risky behaviors and Parkinson's disease in over a million participants, finding protective and risk associations for specific behaviors.

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

GWAS in over one million individuals identify 611 loci across risk tolerance and risky behaviors, revealing shared genetic architecture and implicating glutamatergic and GABAergic neurotransmission.

Differential expression of microRNAs in Alzheimer’s disease brain, blood and cerebrospinal fluid: a systematic review and meta-analysis

This study identifies differentially expressed microRNAs in Alzheimer’s disease across brain, blood, and cerebrospinal fluid through a systematic review and meta-analysis of 147 datasets.

Low frequency and rare coding variation contributes to multiple sclerosis risk

The paper identifies low-frequency coding variants contributing to multiple sclerosis risk using a large case-control study.

Evidence for a potential role of miR-1908-5p and miR-3614-5p in autoimmune disease risk using genome-wide analyses

This study identifies miR-1908-5p and miR-3614-5p as potential regulators of autoimmune disease risk through GWAS and eQTL analyses of immune cell data.

Field synopsis and systematic meta-analyses of genetic association studies in isolated dystonia

This study performs a systematic meta-analysis of genetic association studies in isolated dystonia, identifying significant signals in TOR1A, DRD1, and ARSG but finding no single variant with strong association.