Author

Osborne Seshie

Wake Forest University Health Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 4 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:rat· 6 Approach:statistical model· 5 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:GWAS / association mapping· 2 Research Focus:differential expression· 1

Frequent Co-Authors

Leah C. Solberg WoodsiD· 6 shared Alexandria SzalanczyiD· 4 shared Aron M. GeurtsiD· 3 shared Jason Klotz· 3 shared Michael N. GrzybowskiiD· 3 shared William S. J. ValdariD· 3 shared Aaron W. DealiD· 2 shared Angela BeesoniD· 2 shared

Activity by Year

2022-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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6 shared papersGenetics

Leah C. Solberg WoodsORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats

Montana Kay Lara, Lieselot L. G. Carrette, Thiago Missfeldt Sanches, Oksana Polesskaya, Alicia Avelar, Angela Beeson, Hassiba Beldjoud, Brent Boomhower, Molly Brennan, Denghui Chen, Riyan Cheng, Lindsey China, Apurva S. Chitre, Dana Conlisk, McKenzie J. Fannon, , Olivier George

This study performs a GWAS on cocaine self-administration in rats, identifying six genome-wide significant loci, including one linked to carboxylesterase genes involved in cocaine metabolism.

Nature Communications · Jun 11, 2026Peer-reviewedGenetics

Changes in Environmental Stress over COVID-19 Pandemic Likely Contributed to Failure to Replicate Adiposity Phenotype Associated with Krtcap3

Alexandria Szalanczy, Gina Giorgio, Emily B. Goff, Osborne Seshie, Michael N. Grzybowski, Jason Klotz, Aron M. Geurts, Eva E. Redei, Leah C. Solberg Woods

The paper investigates the failure to replicate an adiposity phenotype linked to Krtcap3 in rats, hypothesizing that environmental stress changes during the COVID-19 pandemic may have influenced the results.

bioRxiv · Mar 15, 2023 · PreprintMolecular Biology

Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred rats

Thu Hong Le, Wesley L. Crouse, Gregory R. Keele, Katie Holl, Osborne Seshie, Michael Tschannen, Ann L. Craddock, Swapan K. Das, Alexandria Szalanczy, Bailey McDonald, Michael N. Grzybowski, Jason Klotz, Neeraj Sharma, Aron M. Geurts, Chia-Chi Chuang Key, , Leah C. Solberg Woods

Diabetes · Oct 11, 2022Peer-reviewedGenetics

Transcriptome-wide Analyses of Adipose Tissue in Outbred Rats Reveal Genetic Regulatory Mechanisms Relevant for Human Obesity

Wesley L. Crouse, Swapan K. Das, Thu Hong Le, Gregory R. Keele, Katie Holl, Osborne Seshie, Ann L. Craddock, Neeraj Sharma, Mary E. Comeau, Carl D. Langefeld, Gregory A. Hawkins, Richard Mott, William S. J. Valdar, Leah C. Solberg Woods

The paper identifies 554 consensus genes in outbred rats and humans associated with body weight and BMI, revealing shared genetic regulatory mechanisms relevant for obesity.

Physiological Genomics · Apr 25, 2022Peer-reviewedGenomics

Sex and genetic specific effects on behavioral, but not metabolic, responses to a high fat diet in heterogeneous stock rats

Aaron W. Deal, Andrew L. Thurman, Osborne Seshie, Alexandria Szalanczy, Angela Beeson, Mackenzie Cockerham, Ellen L Risemberg, Anne Lenzo, Noelle Ozimek, Carl D. Langefeld, William S. J. Valdar, Leah C. Solberg Woods

This study shows that high fat diet affects metabolic health similarly in male and female HS rats but only males show altered behavioral responses, with genetic factors influencing both outcomes.

bioRxiv · Mar 25, 2022 · PreprintGenetics

Keratinocyte-Associated Protein 3 is a novel gene for adiposity with differential effects in males and females

Alexandria Szalanczy, Emily B. Goff, Osborne Seshie, Aaron W. Deal, Michael N. Grzybowski, Jason Klotz, Chia-Chi C Key, Aron M. Geurts, Leah C. Solberg Woods

This study confirms that Krtcap3 affects adiposity and demonstrates sex-specific effects on body weight, food intake, and insulin sensitivity in rats.

bioRxiv · Feb 20, 2022 · PreprintGenetics