Christos Spanos

The paper identifies how Spo13Meikin rewires the phosphoproteome through kinase activity to drive two meiotic divisions in budding yeast.

This study improves RNA-interactome detection using DIA SILAC over DDA SILAC, achieving higher protein detection and lower variation with single-shot analysis.

The paper shows that Mis18 directly binds to SPB components to recruit Mis18C, promoting CENP-A chromatin assembly independently of centromeres.

The paper identifies DAXX as a novel histone chaperone pathway that deposits H3.3K9me3 before DNA deposition, expanding the histone chaperone network's role in heterochromatin assembly.

The paper identifies the SPARC complex in Trypanosoma brucei, showing it defines RNAPII promoters and regulates transcription start site positioning and directionality.

The paper introduces RP-CONA, a method to identify RNA-protein interaction modulators, and finds quercetin inhibits HuR-pri-miR-7-1 interaction, increasing miR-7 and reducing α-Synuclein.

The paper identifies three TRAMP complexes in yeast and shows Trf4/Trf5 confer substrate specificity, with TRAMP binding co-enriching functionally related mRNAs.

The paper identifies Hap2-Ino80's role in promoting de novo CENP-A chromatin assembly by facilitating transcription and H3 turnover at centromeres.

This study identifies the PRY/SPRY domain of TRIM25 as its RNA-binding region and shows its role in ubiquitination.

The paper identifies H2A.ZPht1 and Swr1 as essential for de novo CENP-A/Cnp1 assembly at centromeres in fission yeast.