Edward O. Mann

The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning

This study shows that the superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning by developing neuronal responses to the CS and requiring convergence of visual, dopamine, and serotonin inputs.

Calcium-permeable AMPAR in hippocampal parvalbumin-expressing interneurons protect against memory interference

This study shows that reducing Ca2+-permeable AMPARs in PV+ interneurons impairs working memory and reversal learning but not initial memory acquisition.

An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour.

The paper identifies orexin-sensitive layer 6 neurons in the prefrontal cortex that regulate cortical excitability and anxiety behaviour.

An axonal brake on striatal dopamine output by cholinergic interneurons

This study shows that cholinergic interneurons in the striatum use nicotinic receptors to limit dopamine release by depressing axonal depolarization and calcium summation.

Oscillatory-Quality of sleep spindles: from properties to function

This study introduces a new metric, oscillatory Quality (o-Quality), to quantify sleep spindle oscillatory strength in mice and links it to functional roles in sleep.

Neuronal-spiking-based closed-loop stimulationduring cortical ON and OFF states in freely moving mice

This paper develops a closed-loop stimulation method using neuronal spiking activity to detect ON and OFF states during slow oscillations in freely moving mice.

Miro1-dependent Mitochondrial Dynamics in Parvalbumin Interneurons

This study investigates the role of Miro1 in mitochondrial dynamics of parvalbumin interneurons and shows its impact on neuronal signaling and network synchronization.

Complementary roles for parvalbumin and somatostatin interneurons in the generation of hippocampal gamma oscillations

This study investigates the roles of parvalbumin and somatostatin interneurons in generating slow and fast gamma oscillations in the mouse hippocampus using optogenetics.

The role of the hypothalamus in cortical arousaland sleep homeostasis

This study shows that hypothalamic stimulation increases cortical activity and accelerates sleep pressure buildup, indicating the hypothalamus regulates both state transitions and within-state arousal intensity.

Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter

The paper investigates short-term plasticity in dopamine release in the striatum, finding that it is primarily governed by axonal properties and the dopamine transporter rather than initial release levels.

Motor cortex can modulate somatosensory processing via cortico-thalamo-cortical pathway

This study shows that motor cortex modulates somatosensory processing through a cortico-thalamo-cortical pathway, with thalamic circuits playing a key role in tactile suppression.