Frano Vučković

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

This study identifies 16 new genetic loci associated with plasma N-glycosylation in 10,000 individuals and links them to liver disease and inflammatory proteins.

Total cell N-glycosylation is altered during neuronal differentiation of iPSC to NSC and is disturbed by trisomy 21

This study compares N-glycosylation profiles of iPSCs and NSCs from DS and non-DS individuals, finding altered glycan structures in T21 cells during neural differentiation.

Mapping of the gene network that regulates glycan clock of ageing

The paper identifies 16 genomic loci associated with IgG galactosylation through GWAS and validates three genes using CRISPR/dCas9 in an in vitro system.

Human-specific features and developmental dynamics of the brain N-glycome

The paper characterizes the evolution of the brain N-glycome across primates, finding increased complexity and human-specific sialic acid linkage changes.

Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction

This study shows that young porcine plasma treatment reduces epigenetic age in multiple rat organs and improves physiological function.

Exome sequencing reveals aggregates of rare variants in glycosyltransferase and other genes influencing immunoglobulin G and transferrin glycosylation

The paper uses exome sequencing to identify rare variants in glycosyltransferase genes affecting transferrin and IgG glycosylation, linking them to disease-related traits.

Same role but different actors: genetic regulation of post-translational modification of two distinct proteins

The paper identifies genetic loci regulating glycosylation of transferrin and IgG, finding both shared and protein-specific associations and proposing tissue-specific transcription factor regulation.

Defining the genetic control of human blood plasma N-glycome using genome-wide association study

This study identifies twelve genetic loci associated with human blood plasma N-glycome composition through genome-wide association analysis, revealing both direct and indirect genetic influences on glycosylation.