Ken Raj

A Physics-based Model Reveals Mechanisms of Epigenetic Memory

This paper introduces a physics-based model explaining how cells maintain histone methylation patterns after division, validated by simulations and experimental data.

Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction

This study shows that young porcine plasma treatment reduces epigenetic age in multiple rat organs and improves physiological function.

DNA methylation aging and transcriptomic studies in horses

This paper develops epigenetic clocks for horses using DNA methylation data from multiple tissues, showing age-related CpGs are near developmental genes and that castration does not significantly affect aging rate.

Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity

The paper develops epigenetic clocks for pigs and identifies methylation differences between domestic and minipigs, linking them to obesity and aging-related genes.

Epigenetic clock and methylation studies in the rhesus macaque

This paper develops epigenetic clocks for rhesus macaques using methylation data from multiple tissues, showing high cross-species correlation with vervet monkeys.

DNA methylation age analysis of rapamycin in common marmosets

This paper develops epigenetic clocks for common marmosets using DNA methylation data and tests rapamycin's effect on epigenetic age, finding no significant impact.

Epigenetic clock and methylation studies in cats

This paper develops epigenetic clocks for domestic cats using methylation profiles from a custom Infinium array, creating three clocks including dual-species human-cat clocks.

Epigenetic clock and methylation studies in elephants

This paper develops epigenetic clocks for African and Asian elephants using DNA methylation data to estimate age and identify age-related CpGs and their associated genes.

Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging

This paper develops epigenetic clocks for bovine oocytes and evaluates their ability to estimate chronological age and reveal differences in aging between oocytes and blood.

Epigenetic clock and methylation studies in dogs

This paper develops epigenetic clocks for dogs to estimate age and mortality risk, and identifies methylation sites linked to breed weight and lifespan.

DNA methylation clocks show slower progression of aging in naked mole-rat queens

This study develops DNA methylation clocks for naked mole-rats and finds that queens age more slowly than non-breeders, suggesting a link between reproductive status and epigenetic aging.

Pan-primate DNA methylation clocks

This study develops pan-primate epigenetic clocks and sex predictors using DNA methylation data from 37 primate species, achieving high accuracy for age estimation across species.

Reversing age: dual species measurement of epigenetic age with a single clock

This study develops epigenetic clocks for rat and human tissues and shows that young plasma treatment reduces epigenetic age in multiple tissues and improves organ function.