Author

Daniela Ellen Aust

University Hospital Carl Gustav CarusORCID 0000-0002-4867-8852Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

Daniela Friedland· 3 shared Eyke SchönigeriD· 3 shared Jürgen WeitziD· 3 shared Marius DistleriD· 3 shared Michele SolimenaiD· 3 shared Nicole Kipke· 3 shared Anke M. Schulte· 2 shared Flavia MarzettaiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Daniela Friedland

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pre-cancerous Niche Remodelling Dictates Nascent Tumour Survival

Greta Skrupskelyte, Jesús Eduardo Rojo Arias, Harikrishnan Ajith, Y. Dang, D. Rossetti, S. Han, M. K. S. Tang, Maria Teresa Béjar, Bartomeu Colom, J. C. Fowler, K. Murai, W. Knight, Daniela Ellen Aust, M. H. H. Schmidt, József Jászai, , Maria Pilar Alcolea

The paper shows that pre-cancerous niche remodeling by early tumour cells determines nascent tumour survival in mice.

Nature · Mar 4, 2026Peer-reviewedCancer Biology

Post-transcriptional regulation of insulin mRNA storage by G3BP1/2+ condensates in beta cells

Esteban Quezada, Jovana Vasiljević, Akshaye Pal, Carla Münster, Daniela Friedland, Eyke Schöniger, Anke Sönmez, Annika Seiler, Pascal Roch, Carolin Wegbrod, Katharina Ganß, Klaus-Peter Knoch, Nicole Kipke, Simon Alberti, Rita Nano, , Michele Solimena

The paper shows that G3BP1/2 form condensates with insulin mRNA in beta cells, which dissolve upon glucose stimulation, regulating insulin mRNA storage and translation.

bioRxiv · May 25, 2024 · PreprintMolecular Biology

Identification of a unique transcriptomic signature associated with islet amyloidosis

Marko Barovic, Klaus Steinmeyer, Nicole Kipke, Eyke Schöniger, Daniela Friedland, Flavia Marzetta, Almuth Forberger, Gustavo Bruno Baretton, Jürgen Weitz, Daniela Ellen Aust, Mark R. Ibberson, Marius Distler, Anke M. Schulte, Michele Solimena

This study identifies transcriptomic changes in islet amyloidosis using RNA sequencing and finds a gene co-expression module linked to the condition.

bioRxiv · Nov 9, 2022 · PreprintSystems Biology

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes

Leonore Wigger, Marko Barovic, Andreas‐David Brunner, Flavia Marzetta, Eyke Schöniger, Florence Mehl, Nicole Kipke, Daniela Friedland, Frédéric Burdet, Camille Kessler, Mathias Lesche, Bernard Thorens, Ezio E. Bonifacio, Cristina Legido‐Quigley, Pierre Barbier Saint Hilaire, , Michele Solimena

This study uses multi-omics analysis of pancreatic islet donors to show heterogeneous beta cell changes associated with type 2 diabetes progression.

Nature Metabolism · Jun 28, 2021Peer-reviewedBioinformatics