Harald Schwalbe

Extracellular protein catabolism drives regulated nitrogen handling and ammonia buffering in acute myeloid leukemia

This study shows AML cells use extracellular protein catabolism to supply amino acids and manage nitrogen, with GS/GLUL playing a key role in ammonia buffering and disease progression.

Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA Triplex Element

The paper shows that Fendrr's triplex forming sequence is important for regulating fibrosis-related genes during lung development, and that Fendrr works with Wnt signaling to control these genes.

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

The paper identifies HIF1α-AS1 as a DNA:DNA:RNA triplex-forming lncRNA that interacts with the HUSH complex to repress gene expression and modulates angiogenesis in pulmonary hypertension.

Quantitative modeling of the function of kinetically driven transcriptional riboswitches

The paper develops a kinetic modeling framework for transcriptional riboswitches, showing that transcription rate and metabolite concentration dynamics affect gene regulation.