Author

Islam Alshamleh

Children's Medical CenterORCID 0000-0001-6714-3602Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Amirhossein Barati SedehiD· 1 shared Bernhard BrüneiD· 1 shared Bjoern Haeupl· 1 shared Celestine Aguilar Montero· 1 shared Christian BrandtsiD· 1 shared Christina MuhsiD· 1 shared Claudia Fernandes· 1 shared Daniela S. KrauseiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

Amirhossein Barati SedehORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Extracellular protein catabolism drives regulated nitrogen handling and ammonia buffering in acute myeloid leukemia

Nina Kurrle, Philipp Makowka, Vera Schlipfenbacher, Johanna Kreitz, Islam Alshamleh, Marcel Seibert, Sifora Kaleab, Celestine Aguilar Montero, Silvia Marín, Dominik Christian Fuhrmann, Florian Gatzke, Claudia Fernandes, Nidhi Preman, Bjoern Haeupl, Sebastian Wolf, , Hubert L. Serve

This study shows AML cells use extracellular protein catabolism to supply amino acids and manage nitrogen, with GS/GLUL playing a key role in ammonia buffering and disease progression.

bioRxiv · Aug 28, 2026 · PreprintCancer Biology

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT

Zheng Wu, Phong T. Nguyen, Varun Sondhi, Run-Wen Yao, Zhifang Lu, Tao Dai, Jui‐Chung Chiang, Feng Cai, Imani M. Williams, Eliot B. Blatt, Zeng‐Fu Shang, Ling Cai, Jing Zhang, Mya D. Moore, Islam Alshamleh, , Ralph J. DeBerardinis

This study identifies NUDT5 as a regulator of purine metabolism and thiopurine sensitivity by interacting with PPAT, independent of its known enzymatic activity.

Science · Nov 6, 2025Peer-reviewedBiochemistry