Author

Van Karlyle Morris

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-4911-2252Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:multiome· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Natalie Wall FowlkesiD· 2 shared Saikat ChowdhuryiD· 2 shared Scott KopetziD· 2 shared Abhinav K. JainiD· 1 shared Ajay Kumar SawiD· 1 shared Akash R. BodaiD· 1 shared Alexey V. SorokiniD· 1 shared Amanda AndersoniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Natalie Wall FowlkesORCID

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2 papers

Recent·Most cited

Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory Circuits During Response to MAPK Inhibition in BRAF-mutant Colorectal Cancer

Hey Min Lee, Zhao Zheng, Alexey V. Sorokin, Chi Wut Wong, Stefania Napolitano, Saikat Chowdhury, Preeti Kanikarla Marie, Anand Kamal Singh, Veena Kochat, Christopher Aaron Bristow, Sanjana Srinivasan, Michael D. Peoples, Emre Arslan, Jumanah Yousef Alshenaifi, Oscar Eduardo. Villarreal, , Scott Kopetz

This study shows BET + MAPK inhibitors improve efficacy against BRAFV600E CRC by inducing epigenetic reprogramming and cellular plasticity through enhancer dynamics disruption.

Clinical Cancer Research · May 8, 2026Peer-reviewedCancer Biology

IL-1R1 Blockade Enhances CD40 Agonist-Mediated Immune Responses but Fails to Increase Efficacy or Mitigate Hepatotoxicity in Pancreatic Cancer

Akash R. Boda, Irfan N. Bandey, Saikat Chowdhury, Sadhna Aggarwal, Venugopala Reddy Mekala, Natalie Wall Fowlkes, Jason Roszik, Michael A. Curran, Van Karlyle Morris, Scott Kopetz, Manisha Singh

This study investigates the effect of IL-1R1 blockade on CD40 agonist therapy in PDAC, finding it does not improve efficacy and worsens liver toxicity.

bioRxiv · Feb 23, 2025 · PreprintCancer Biology