HypoAD: volumetric and single-cell analysis reveals changes in the human hypothalamus in aging and Alzheimer's disease
Doudou Yu, Jürgen Germann, Ghulam Murtaza, Kaitlyn H. Hajdarovic, Kelsey R. Babcock, Shiva Kazempour Dehkordi, Alexander C. Jackson, Ivana Delalle, Miranda E. Orr, Habil Zare, Ritambhara Singh, William Stafford Noble, Andrei G. Vlassenko, Manu S. Goyal, Ashley E. Webb
HypoAD integrates MRI and snRNA-seq to analyze hypothalamic changes in aging and Alzheimer's disease, revealing volume and gene expression alterations in key subregions and cell types.
bioRxiv · Oct 8, 2025 · PreprintNeuroscience