Peter C. Harris

Leveraging genomic biobanks to enhance genetic testing outcomes for kidney disease

This study evaluates genetic testing outcomes for kidney disease, finding 34% of patients had pathogenic variants, 52% had variants of uncertain significance (VUS), and multidisciplinary review with biobank data helped reclassify some VUS.

Induced Proteinuria Enhances Adeno-Associated Virus Transduction of Renal Tubule Epithelial Cells After Intravenous Administration

The paper shows that inducing proteinuria enhances viral vector transduction of renal tubule epithelial cells after intravenous administration.

Activation of PIEZO1 Inhibits Kidney Cystogenesis

This study shows that activating PIEZO1 reduces cyst formation in kidney cells and ex vivo models, suggesting it could be a therapeutic target for ADPKD.

mtor Haploinsufficiency Ameliorates Renal Cyst Formation in Adult Zebrafish tmem67 Mutants

This paper establishes an adult zebrafish model of PKD using tmem67 mutants, identifies mTOR inhibition as a potential therapy, and reveals ciliary abnormalities as a primary defect.