Ke Wang

Super-enhancer interactomes from single cells link clustering and transcription

The paper maps single-cell super-enhancer interactomes, revealing that SEs form loose communities linked to transcriptional bursts.

Deep learning the cis-regulatory code of chromatin dynamics during cellular reprogramming

The paper uses deep learning to analyze chromatin accessibility and gene expression during reprogramming, revealing how TF concentrations and motif syntax influence cis-regulatory networks.

Schizophrenia Risk Mapping and Functional Engineering of the 3D Genome in Three Neuronal Subtypes

The paper maps 3D chromatin structures in neuronal subtypes and shows how schizophrenia risk loci reorganize during differentiation, linking regulatory loops to gene function.

Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease

This study uses single-cell chromatin accessibility analysis to identify developmental trajectories and non-coding mutations associated with congenital heart disease.