The paper shows that ileitis disrupts bile acid (BA) pool balance, altering immune regulation by affecting BA receptor interactions and Th17 cell function.

bioRxiv · Sep 18, 2026 · PreprintImmunology

High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds

Diwen Yang, Xiaoyun Wang, Jiabao Liu, Yufeng Gong, Pranav Nair, Jianxian Sun, Xing Qian, Jingyuan Cui, Hong Zeng, Aiping Dong, Rachel Harding, N. Burgess-Brown, Tyler S. Beyett, Datong Song, Henry M. Krause, , Hui Peng

The paper uses high-throughput affinity-selection mass spectrometry to identify protein targets of ToxCast and PFAS compounds, discovering novel interactions and revealing distinct binding patterns of legacy and replacement PFAS.

Proceedings of the National Academy of Sciences · Jun 5, 2026Peer-reviewedPharmacology & Toxicology

Quantifying forms and functions of intestinal bile acid pools in mice

Koichi Sudo, Amber Delmas Eliason, Shannon M. Soucy, Kaitlyn E. Barrack, Jiabao Liu, Akshaya Balasubramanian, Chengyi Jenny Shu, Michael J. James, Courtney Lynn Hegner, Henry D. Dionne, Alexander Rodriguez‐Palacios, Henry M. Krause, George A. O’Toole, Saul J. Karpen, Paul A. Dawson, , Mark S. Sundrud

The paper quantifies ileal bile acid pools in mice and shows that Asbt-mediated transport dominates their size and composition, with loss of Asbt reducing pool size and altering transcriptional responses.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2024Peer-reviewedPhysiology