This study identifies LAMP2B as a mediator of microlipophagy, showing its role in preventing obesity and related metabolic disorders through enhanced lipid hydrolysis.

Cell Reports · Jun 1, 2025Peer-reviewedCell Biology

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD

Yuzo Fujino, Morio Ueyama, Taro Ishiguro, Daisaku Ozawa, Hayato Ito, Toshihiko Sugiki, Asako Murata, Akira Ishiguro, Tania F. Gendron, Kohji Mori, Eiichi Tokuda, Tomoya Taminato, Takuya Konno, Akihide Koyama, Yuya Kawabe, , Yoshitaka Nagai

This study shows FUS suppresses RAN translation by modulating G-quadruplex structure of GGGGCC repeat RNA, reducing neurodegeneration in C9-ALS/FTD model flies.

eLife · Feb 13, 2023Peer-reviewedNeuroscience

Distinct synaptic and related transcriptional abnormalities in neonatal, childhood and mature autism model of primate: implications for early-age therapeutic intervention

Satoshi Watanabe, Tohru Kurotani, Tomofumi Oga, Jun Noguchi, Risa Isoda, Akiko Nakagami, Kazuhisa Sakai, Keiko Nakagaki, Kayo Sumida, Kohei Hoshino, Koichi Saito, Izuru Miyawaki, Masayuki Sekiguchi, Keiji Wada, Takafumi Minamimoto, Noritaka Ichinohe

This study identifies distinct synaptic and gene expression abnormalities in primate ASD models across developmental stages, suggesting potential targets for early therapeutic intervention.

bioRxiv · Aug 18, 2020 · PreprintNeuroscience

AUTS2 regulation of synapses for proper synaptic inputs and social communication.

Kei Hori, Kunihiko Yamashiro, Taku Nagai, Wei Shan, Saki F. Egusa, Kazumi Shimaoka, Hiroshi Kuniishi, Masayuki Sekiguchi, Yasuhiro Go, Shoji Tatsumoto, Mitsuyo Yamada, Reika Shiraishi, Kouta Kanno, Satoshi Miyashita, Asami Sakamoto, , Mikio Hoshino

This study shows that AUTS2 regulates excitatory synapse number to maintain E/I balance, and its loss leads to autistic-like behaviors and increased brain excitability.

iScience · May 18, 2020Peer-reviewedNeuroscience