Author

Dominik Vonficht

German Cancer Research CenterORCID 0000-0002-5579-7083Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

Simon F. HaasiD· 3 shared Andreas TrumppiD· 2 shared Daniel HübschmanniD· 2 shared Judith B. ZauggiD· 2 shared Adriane HalikiD· 1 shared Alejo Rodriguez-FraticelliiD· 1 shared Anastasia SedlmeieriD· 1 shared Angelika FeldmanniD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersCancer Biology

Simon F. HaasORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Multiscale biological interactions define clinical trajectories in acute myeloid leukemia

Jan Bařinka, Sarah Gräßle, Magdalena Pajonk, Rosa Allesøe, Stefanos A. Bamopoulos, Maximilian Mönnig, Caroline Röthemeier, Lea Jopp‐Saile, Dominik Vonficht, Eleni Besiridou, Jana Ihlow, Jan Braune, Evi P. Vlachou, Sergi Beneyto‐Calabuig, Michael Kardorff, , Simon Haas

This study links multiscale biological interactions to clinical outcomes in AML by analyzing single-cell data and developing an analytical framework.

bioRxiv · Aug 26, 2026 · PreprintCancer Biology

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

Esther Rodriguez-Correa, Florian Grünschläger, Tamar Nizharadze, Natasha Anstee, Jude Al-Sabah, Vojtěch Kumpošt, Anastasia Sedlmeier, Congxin Li, Melanie Ball, Foteini Fotopoulou, Jeyan Jayarajan, Ian Ghezzi, Julia Knoch, Megan Druce, Kleo Aurich, , Michael D. Milsom

This study uses single-cell transplantation and mathematical modeling to show that lineage biases in hematopoiesis arise from extrinsic feedback and clonal competition, not intrinsic HSC properties.

Nature Cell Biology · May 25, 2026Peer-reviewedCell Biology

Epithelial cells of the intestine acquire cell-intrinsic inflammation signatures during ageing

Maja C. Funk, Jan Gleixner, Florian Heigwer, Dominik Vonficht, Erica Valentini, Zeynep Aydin, Elena Tonin, Stefania Prete, Sylvia Mahara, Yannick Throm, Jenny Hetzer, Danijela Heide, Oliver Stegle, Duncan T. Odom, Angelika Feldmann, , Michael Boutros

This study shows that aged intestinal epithelial cells exhibit a persistent inflammation signature, marked by MHC class II upregulation and increased chromatin accessibility of inflammation-associated loci.

Developmental Cell · Dec 1, 2023Peer-reviewedGenomics