Giovanni L. Burke

ZNF121 recruits YTHDF2 to modulate mRNA stability

The paper identifies ZNF121 as a cofactor that enhances YTHDF2-mediated mRNA decay by facilitating its binding to target transcripts, thereby modulating mRNA stability and cell-cycle regulation.

H3.3 De Novo Mutations Alter Lysine 36 Methylation via Distinct Mechanisms

This study investigates how BLBS-causing H3.3 mutations affect H3K36 methylation and effector protein binding, revealing molecular similarities across mutations.

Recruitment of the m6A/Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48

This study identifies ZBTB48 as a regulator of FTO's substrate selectivity by facilitating its binding to m6A/m6Am-containing RNAs, affecting RNA decay and cancer cell growth.

Sumoylation is largely dispensable for normal growth but facilitates heat tolerance in yeast

This study shows that sumoylation is largely dispensable for normal yeast growth but essential for heat tolerance, as reduced Ubc9 activity leads to temperature sensitivity and transcriptional dysregulation.

SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAs

This study identifies SARS-CoV-2 N protein interactions with host proteins and mRNAs, showing it attenuates stress granule formation and alters gene expression.