Darlene Rahbarian

Precocious maturation and Purkinje cell dysfunction in the mouse Chd8 haploinsufficient cerebellum

This study examines the effects of Chd8 haploinsufficiency on cerebellar development and function in mice, revealing cell-type-specific transcriptomic and physiological changes.

Complementary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

The paper develops murine and zebrafish Wac deletion models to study DeSanto-Shinawi Syndrome, finding craniofacial, behavioral, and neurodevelopmental phenotypes similar to the human condition.

Persistent cortical excitatory neuron dysregulation in adult Chd8 haploinsufficient mice.

This study identifies persistent excitatory neuron dysfunction in Chd8 haploinsufficient mice through single nucleus transcriptomics and behavioral analysis.

Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1 mutations

This paper investigates functional impairments in Syngap1 mutant mice, identifying translational biomarkers in both in vitro and in vivo neurophysiological data.