Author

Viviana Macarelli

University of CambridgeORCID 0000-0002-5875-8290Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Florian T. MerkleiD· 3 shared Dmytro ShepiloviD· 2 shared Hsiao‐Jou Cortina CheniD· 2 shared Alix Schwiening· 1 shared Andrian YangiD· 1 shared Bavesh Jawahar· 1 shared Christine RowleyiD· 1 shared Constanza AlcainoiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersNeuroscience

Florian T. MerkleORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Proximity proteomics of primary cilia in human hypothalamic neurons

Viviana Macarelli, Tommy J Sroka, Jan N. Hansen, Ulrika Axelsson, David U. Mick, Florian T. Merkle

The paper identifies ciliary proteins in human hypothalamic neurons and finds new therapeutic targets for obesity, including LPAR1, which mediates ciliary shortening.

bioRxiv · May 11, 2025 · PreprintCell Biology

GLP-1R agonists activate human hypothalamic neurons

Simone Mazzaferro, Hsiao‐Jou Cortina Chen, Olivier Cahn, Andrian Yang, Dmytro Shepilov, Eugene Seah, Jiahui Chen, Bavesh Jawahar, Constanza Alcaino, Viviana Macarelli, Iman D. Mali, John A. Tadross, Fiona Mary Gribble, Frank M. Reimann, John C. Marioni, Florian T. Merkle

This study investigates how GLP-1R agonists affect human hypothalamic neurons derived from pluripotent stem cells, finding they induce depolarization, increased firing, and gene expression changes.

bioRxiv · Apr 2, 2024 · PreprintNeuroscience

Metformin acts directly in the brain to slow features of neurodegeneration.

Edward C. Harding, Hsiao‐Jou Cortina Chen, Dmytro Shepilov, Marc Welzer, Viviana Macarelli, Alix Schwiening, Christine Rowley, Sanya Aggarwal, Dean Swinden, Deborah Kronenberg‐Versteeg, Florian T. Merkle

This study shows metformin can slow neurodegeneration features in mice, even in metabolically healthy individuals, by acting directly in the brain.

bioRxiv · Jul 18, 2023 · PreprintNeuroscience