This study shows MUTYH prevents telomere shortening and genomic instability in cancer cells under chronic 8-oxoG damage by resolving BER intermediates.

Biomolecules · Aug 26, 2026Peer-reviewedMolecular Biology

MIXL1 Activation in Endoderm Differentiation ofHuman Induced Pluripotent Stem Cells

Pierre Osteil, Sarah Withey, Nicole Santucci, Nader Aryamanesh, Ignatius Pang, Nazmus Salehin, Jane Q. J. Sun, Annie Qin, Jiayi Su, Hilary Knowles, Xiucheng Bella Li, Simon Cai, Ernst Jurgen Wolvetang, Patrick Tam

The paper shows that activating MIXL1 in hiPSCs improves endoderm differentiation and maturation.

Stem Cell Reports · Apr 24, 2025Peer-reviewedDevelopmental Biology

Characterization of the mesendoderm progenitors in the gastrulating mouse embryo

V. Pragathi Masamsetti, Nazmus Salehin, Hani Jieun Kim, Nicole Santucci, Megan Weatherstone, Riley McMahon, Lee L. Marshall, Hilary Knowles, Jane Q. J. Sun, Josh B. Studdert, Nader Aryamanesh, Ran Wang, Naihe Jing, Pengyi Yang, Pierre Osteil, Patrick Tam

The paper identifies mesendoderm progenitor cells in mouse embryos and shows their contribution to endoderm and mesoderm lineages through lineage tracing and analysis of Mixl1 function.

Developmental Cell · Mar 24, 2025Peer-reviewedDevelopmental Biology

Cumulative pregnancy and postnatal environmental exposures impact social behaviour in male mice associated with epigenetic, ribosomal, and immune dysregulation

Morgan C. Bucknor, Brooke A. Keating, Velda Xinying Han, Brian Gloss, Pinki Dey, Nader Aryamanesh, Lee L. Marshall, Mark Evan Graham, Ruwani Dissanayake, Xianzhong Lau, Shrujna Patel, Stela P. Petkova, Anand Gururajan, Russell Clive Dale, Markus J. Hofer

The paper shows that early life environmental exposures in male mice lead to neurodevelopmental behaviors and molecular changes, while females are unaffected.

bioRxiv · Mar 19, 2025 · PreprintDevelopmental Biology