Sarah Elizabeth Blutt

RSV & rhinovirus coinfection order dictates outcome via type III interferon-mediated interference in infant respiratory epithelium

This study shows that the order of RSV and RV infection in infants determines disease outcome through type III interferon-mediated viral interference.

Lipoproteins modulate the uptake and biological functionof cationic cell-penetrating peptides across the animal lineage.

This study identifies lipoprotein-mediated endocytosis as a conserved mechanism for cationic cell-penetrating peptides across animal lineages, showing it modulates their antimicrobial function.

D-alanine aminotransferase (Dat) promotes Staphylococcus aureus colonization fitness on human nasal respiratory epithelium

This study identifies D-alanine aminotransferase (Dat) as critical for Staphylococcus aureus colonization of human nasal epithelium, showing its role in D-alanine production and fitness in this environment.

RSV Infects the Human Nasal Epithelium via the Basolateral Route with Distinct Subgroup Infectivity and Basal Cell Tropism

This study shows RSV can infect respiratory epithelium via the basolateral route, targeting basal cells, with RSV/B/BA showing higher basolateral infectivity than RSV/A/ON.

Streptococcus pneumoniae colonization modulates human nasal epithelial responses to respiratory syncytial virus infection

This study shows that Streptococcus pneumoniae precolonization reduces RSV levels and modulates epithelial transcriptional responses to RSV infection more than other nasal bacteria.

Nasal microbionts differentially colonize and elicit cytokines in human nasal epithelial organoids

This study uses human nasal epithelial organoids to investigate how different bacteria colonize nasal tissue and induce cytokine responses, finding differential effects on chemokines and inflammasome signaling.

Human bladder organoids model urinary tract infection and bacteriophage therapy

This study develops human bladder organoids to model UTIs and phage therapy, showing phage reduces bacterial loads and inflammation during infection.

Insights into Human Norovirus Cultivation in Human Intestinal Enteroids

This paper reports the cultivation of human noroviruses in human intestinal enteroids, revealing segment- and strain-specific differences in viral replication and highlighting the utility of genetically modified enteroids for broader strain cultivation.

Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids

This study identifies major sources of transcriptomic variation in human intestinal organoids, showing that culture methods like substrate and format have large effects compared to experimental manipulations.