Ye Zhang

This study shows that prenatal lead exposure biases neural cell fate in human brain development by increasing neurons and reducing astrocytes through epigenetic changes.

This paper develops a humanized mouse model with human glia and immune cells to study HIV CNS infection and neuroinflammation, showing HIV replication and synapse loss in the brain.

The paper analyzes the secreted proteome of oligodendrocytes and progenitor cells to reveal their roles in extracellular matrix formation and inflammation regulation.

This study identifies intercellular signaling pathways involved in vascular dementia repair and demonstrates therapeutic potential through drug intervention.

The paper investigates how microglia and the extracellular matrix influence cognitive aging by analyzing ECM composition, microglial interactions, and their relationship with synapses and behavior.

This study identifies Prdm16 and Vcam1 as regulators of postnatal radial glia disappearance and the termination of cortical neurogenesis.

This study identifies transcriptomic signatures of human astrocytes across age, sex, and disease states, revealing changes in synaptic function, ionic homeostasis, and tumor microenvironment interactions.

The paper uses CRISPRi screens and single-cell transcriptomics in human astrocytes to identify regulators of inflammatory reactive states and their relevance in disease.

The paper compares gene expression and stress responses in human and mouse astrocytes, finding conserved and divergent features that may explain differences in disease models.

This study uses single-cell RNAseq to analyze infiltrating neoplastic cells in human glioblastoma, identifying consistent gene signatures and distinct myeloid cell populations across patients.