Kristen Fortney

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.

Inhibition of NLRP3 by a CNS-penetrating indazole scaffold

This paper identifies and characterizes BAL-1516, a CNS-penetrating NLRP3 inhibitor that blocks inflammasome formation and shows potential for treating neuroinflammatory diseases.

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome

The paper identifies BMI-associated metabolites using untargeted metabolomics and causal inference, finding both known and unknown metabolites with causal links to obesity.

PAIRUP-MS: Pathway Analysis and Imputation to Relate Unknowns in Profiles from Mass Spectrometry-based metabolite data

PAIRUP-MS imputes and annotates unknown metabolite signals in mass spectrometry data, improving pathway analysis and meta-analysis power for metabolomics studies.