This study shows that platyfish and swordtails (Xiphophorus species) regenerate their hearts with persistent scarring, unlike zebrafish, due to differences in myocardium structure and inflammatory response.

bioRxiv · Sep 23, 2025 · PreprintDevelopmental Biology

RNA polymerase II transcription with partially assembled TFIID complexes

Vincent Hisler, Paul Bardot, Dylane Detilleux, Matthieu Stierlé, Emmanuel García Sánchez, Claire Richard, Lynda Hadj Arab, Cynthia Ehrhard, Bastien Morlet, Yavor Hadzhiev, Matthieu Jung, Stéphanie Le Gras, Luc Négroni, Ferenc Müller, Làszlò Tora, Stéphane D. Vincent

This study shows that partially assembled TFIID complexes can initiate RNA polymerase II transcription but cannot fully replace holo-TFIID over time.

bioRxiv · Nov 27, 2023 · PreprintMolecular Biology

SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells

Véronique Fischer, Vincent Hisler, Elisabeth Scheer, Elisabeth Lata, Bastien Morlet, Damien Plassard, Dominique Helmlinger, Didier Devys, Làszlò Tora, Stéphane D. Vincent

This study shows that SUPT3H is not essential for SAGA complex assembly or overall Pol II transcription but is required for mESC growth and self-renewal.

Nucleic Acids Research · Jul 24, 2022Peer-reviewedMolecular Biology

TBPL2/TFIIA complex establishes the maternal transcriptome by an oocyte-specific promoter usage

Changwei Yu, Nevena Cvetešić, Vincent Hisler, Kapil Gupta, Tao Ye, Emese Gazdag, Luc Négroni, Petra Hájková, Imre Berger, Boris Lenhard, Ferenc Müller, Stéphane D. Vincent, Làszlò Tora

The paper shows that the TBPL2/TFIIA complex establishes the oocyte transcriptome by using a specific TSS recognition code through oocyte-specific promoter usage.

Nature Communications · Dec 22, 2020Peer-reviewedMolecular Biology