Roan H van Scheppingen

Scalable proxiloids enable human-relevant assessment of kidney proximal tubule toxicity

This study introduces proxiloids, a scalable human-induced pluripotent stem cell differentiation method that models kidney proximal tubule toxicity more accurately than existing methods.

Same-section spatial metabolo-transcriptomics using Stereo-meta-seq reveals DHA-driven kidney maturation

This study introduces Stereo-meta-seq to integrate spatial metabolomics and transcriptomics in human kidney development, revealing DHA's role in proximal tubule maturation.

Normothermic human kidney preservation drives iron accumulation and ferroptosis

This study shows that normothermic kidney preservation with red blood cells causes iron accumulation and ferroptosis, leading to kidney injury, and suggests alternatives to mitigate these effects.