Caroline Braeuning

This study shows that spreading α-synuclein alters organelle communication and disrupts neuron-astrocyte mitochondrial quality control.

The paper introduces circVDJ-seq for efficient T cell receptor profiling from single-cell and spatial multi-omics data, revealing distinct immune microenvironments and T cell clonality patterns in various clinical contexts.

The paper constructs a single-nucleus transcriptomic atlas of Arabidopsis floral development and identifies key transcription factors regulating epidermal differentiation.

This study identifies endocardial sprouting angiogenesis as a key mechanism in coronary vessel formation, revealing distinct molecular profiles that shape coronary arteries and veins.

This study shows that spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model by targeting microglia and reducing inflammatory pathways.

This study identifies IL-12 as the main driver of neuroinflammation in Alzheimer's disease by affecting oligodendrocyte survival and neuronal homeostasis in a mouse model.

This paper introduces a nuclei isolation method for plant tissues followed by single-nuclei RNA-seq, enabling transcriptome analysis of various plant species and tissues.

This study benchmarks 13 scRNA-seq protocols to evaluate their effectiveness in characterizing cell types and states for cell atlas projects.