Adolfo García‐Sastre

This paper develops a live attenuated vaccine candidate, LPhTXdNS1, against H5N1 influenza viruses and shows it is safe, immunogenic, and protective in mice.

This study identifies amino acid changes in the PB2 protein of H5N1 HPAIV that enhance replication and pathogenicity in human cells and mice.

This study compares replication and pathogenicity of cattle-origin H5N1 influenza viruses in mammals and birds, finding higher replication efficiency and pathogenicity in human-adapted isolates.

This study shows that combining intramuscular mRNA priming with intranasal protein boosting using a combination adjuvant enhances mucosal B- and T-cell responses against SARS-CoV-2 compared to other vaccination regimens.

This study shows that heterologous immunization primes antigen-specific memory CD4 T cells, enhancing early germinal center response but not antibody generation in influenza infection.

The paper analyzes baseline multi-omic data from influenza vaccine recipients to identify pre-immune states predictive of vaccination responses.

This study identifies critical human host factors involved in SARS-CoV-2 multicycle replication through a genome-scale siRNA screen and validates potential antiviral targets.

This paper evaluates the AVX/COVID-12 vaccine's ability to activate T cells and bind antibodies from vaccinated individuals and SARS-CoV-2-infected patients.

This study evaluates how lipid nanoparticle (LNP) composition and adjuvant combinations affect immune responses and protection in mice vaccinated against influenza.

This study evaluates hybrid immunity in mRNA-vaccinated hamsters during breakthrough infections, finding enhanced cross-reactive immune responses despite low neutralizing antibody titers.

This paper presents a protocol for creating human lung organoid-derived air-liquid interface cultures to study SARS-CoV-2 infection and includes quality control and monitoring methods.

The paper systematically analyzes proteomic and genomic data of SARS-CoV-2 variants to identify how mutations affect viral gene expression, host interactions, and immune evasion.

The paper identifies increased transmissibility in MPXV clade IIb by analyzing genomic low-complexity regions (LCRs) and suggests they may be more informative than SNPs.

The paper generates bat induced pluripotent stem cells and finds they contain endogenous viral sequences, suggesting a deep entanglement between bats and viruses.

The paper identifies a two-factor authentication mechanism used by the innate immune system to detect low-abundance HIV-1 DNA through PQBP1-mediated capsid recognition and cGAS recruitment.

A computational drug repositioning pipeline identifies potential therapeutics for COVID-19 by matching SARS-CoV-2 gene expression signatures to drug profiles.