Nadja Hellmann

RNA G-quadruplexes mediate cooperativity in HNRNPH binding and splicing regulation

The paper investigates how RNA G-quadruplexes enable cooperative binding of HNRNPH and regulate splicing, showing clinical relevance in breast cancer.

The structured hairpin region of the bacterial ESCRT-III protein IM30 orchestrates stress-induced condensate formation

This study identifies the structured hairpin region of IM30 as the driver of stress-induced condensate formation in cyanobacteria, linking membrane stress, pH changes, and phase separation.

Membrane binding of a cyanobacterial ESCRT-III protein crucially involves the helix α1-3 hairpin conserved in all superfamily members

The paper shows IM30 binds membranes via a conserved helical hairpin, initiating assembly into higher-order structures that mediate membrane remodeling, revealing a conserved mechanism across ESCRT-III superfamily members.

The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions

This study shows how PspA rods thin lipid tubules by inducing membrane curvature through N-terminal helix 0 interactions, overcoming bending energy via molecular mechanisms.

Structural basis for Vipp1 membrane binding: From loose coats and carpetsto ring and rod assemblies

This study presents cryo-EM structures of Vipp1 interacting with bacterial membranes, revealing curvature-dependent structural transitions and membrane remodeling mechanisms.