Author

Harriet M. Williams

Jackson Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1

Frequent Co-Authors

Gareth R. HowelliD· 4 shared Michael SasneriD· 4 shared Dylan T. Garceau· 3 shared Gregory W. CarteriD· 3 shared Kevin P. KotredesiD· 3 shared Ravi S. PandeyiD· 3 shared Adrian L. OblakiD· 2 shared Asli UyariD· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Gareth R. HowellORCID

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Author profile →

4 papers

Recent·Most cited

In vivo validation of late-onset Alzheimer's disease genetic risk factors

Michael Sasner, Christoph Preuß, Ravi S. Pandey, Asli Uyar, Dylan T. Garceau, Kevin P. Kotredes, Harriet M. Williams, Adrian L. Oblak, Peter Bor‐Chian Lin, Bridget M Perkins, Disha M. Soni, Cindy Ingraham, Audrey Lee‐Gosselin, Bruce T. Lamb, Gareth R. Howell, Gregory W. Carter

The paper functionally validates 11 genetic risk variants for late-onset Alzheimer's disease using a mouse model and compares transcriptomic effects to human cohorts.

Alzheimer s & Dementia · Apr 30, 2024Peer-reviewedNeuroscience

Metabolomics profiling reveals distinct, sex-specific signatures in the serum and brain metabolomes in the mouse models of Alzheimer's disease

Ravi S. Pandey, Matthias Arnold, Richa Batra, Jan Krumsiek, Kevin P. Kotredes, Dylan T. Garceau, Harriet M. Williams, Michael Sasner, Gareth R. Howell, Rima F Kaddurah-Daouk, Gregory W. Carter

The paper identifies sex-specific metabolomic differences in serum and brain of Alzheimer's disease mouse models, showing model-specific metabolic signatures that align with human APOE4 carriers.

Alzheimer s & Dementia · Apr 27, 2024Peer-reviewedNeuroscience

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

Christoph Preuß, Ravi S. Pandey, Erin Piazza, Alexander D. Fine, Asli Uyar, Thanneer Malai Perumal, Dylan T. Garceau, Kevin P. Kotredes, Harriet M. Williams, Lara M. Mangravite, Bruce T. Lamb, Adrian L. Oblak, Gareth R. Howell, Michael Sasner, Benjamin A. Logsdon, Gregory W. Carter

The paper introduces a NanoString nCounter Mouse AD panel to assess LOAD mouse models by correlating gene expression with human AD modules, showing strong correlation with RNA-Seq data.

Molecular Neurodegeneration · Nov 10, 2020Peer-reviewedNeuroscience

The Alzheimer's disease protective P522R variant of PLCG2, consistently enhances stimulus-dependent PLCγ2 activation, depleting substrate and altering cell function.

Emily Maguire, Georgina Elizabeth Menzies, Tom J. Phillips, Michael Sasner, Harriet M. Williams, Magdalena A. Czubala, Neil Evans, Emma L. Cope, Rebecca Sims, Gareth R. Howell, Emyr Lloyd‐Evans, Julie H. Williams, Nicholas D. Allen, Philip R. Taylor

This paper identifies a protective PLCG2 variant in Alzheimer's disease, showing enhanced PLCγ2 activation and functional changes in immune cells.

bioRxiv · Apr 27, 2020 · PreprintNeuroscience