Lauren Haky

A complex phenotypic assay of mammalian oocyte maturation identifies compounds that block meiotic progression for non-hormonal contraceptive discovery

This study screens compounds to identify those that block meiotic progression in mouse oocytes, offering potential non-hormonal contraceptive candidates.

Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6J mice

This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.

CD38 regulates ovarian function and fecundity via NAD+ metabolism

This study shows CD38 loss increases ovarian NAD+ levels and fecundity in young mice but not in older mice.

Altered germline cyst and oocyte differentiation in Tex14 mutant mice reveal a new mechanism underlying female reproductive life-span

This study shows that Tex14 mutant mice have altered germline cysts and oocyte differentiation, linking germ cell connectivity to oocyte cytoplasmic enrichment and adult reproductive lifespan.