Michael C. Fitzgerald

Chemoproteomic profiling of Plasmodium falciparum Hsp90 inhibition reveals functional link to DNA replication pathways

The paper identifies DNA replication pathways linked to PfHsp90 inhibition in Plasmodium falciparum using chemoproteomic profiling and functional assays.

The KRAS G12C Inhibitor Divarasib Stabilizes RBM39 and Antagonizes Aryl-Sulfonamide Degraders

This study identifies RBM39 as a noncovalent target of the KRAS G12C inhibitor divarasib and reveals an RBM39-INSR signaling axis that influences cytotoxicity.

Discovery of Host-Directed Small Molecules with Broad Anti-Leishmanial Efficacy

The paper screens 343 AR-12 analogs to identify host-directed anti-leishmanial compounds, finding four lead compounds with broad in vitro efficacy and a lysozyme-mediated mechanism.

Small molecules reveal differential shifts in stability and protein binding for G-quadruplex RNA

This paper investigates how small molecules affect RNA G-quadruplex stability and protein binding, revealing bidirectional impacts and specific protein interactions.