Author

John S. Kaddis

City Of Hope National Medical CenterORCID 0000-0002-6752-7670Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Alexandra Coomans de BrachèneiD· 1 shared Alexandra RippaiD· 1 shared Amanda L. PosgaiiD· 1 shared Ângela Castela· 1 shared Arnaud ZaldumbideiD· 1 shared Carmella Evans‐MolinaiD· 1 shared Chih‐Chun LeeiD· 1 shared Clive Henry WasserfalliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPhysiology

Alexandra Coomans de BrachèneORCID

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2 papers

Recent·Most cited

3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes

Alexandra Rippa, Amanda L. Posgai, Seth Currlin, Maigan Brusko, MacKenzie D. Williams, John S. Kaddis, Irina Kusmartseva, Clive Henry Wasserfall, Martha Campbell‐Thompson, Mark A. Atkinson

The paper uses 3D imaging to analyze pancreatic islets in healthy and type 1 diabetes (T1D) individuals, finding that islet size and composition influence their loss in T1D.

Nature Communications · Dec 11, 2025Peer-reviewedPathology

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

Farooq Syed, Olivia Ballew, Chih‐Chun Lee, Jyoti Rana, Preethi Krishnan, Ângela Castela, Staci A. Weaver, Namratha Shivani Chalasani, Sofia Thomaidou, Stéphane Demine, Garrick Chang, Alexandra Coomans de Brachène, Maria Inês Alvelos, Eugenia Martin Vázquez, Lorella Marselli, , Carmella Evans‐Molina

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

EBioMedicine · May 6, 2025Peer-reviewedPhysiology