Author

Koby Baranes

Wellcome/MRC Cambridge Stem Cell InstituteORCID 0000-0002-6887-3241Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Mark KotteriD· 4 shared Noah PouliniD· 2 shared Aiwei ZengiD· 1 shared Alon LoeffleriD· 1 shared Andrei MihutiD· 1 shared Andrew D. BealeiD· 1 shared Annelies QuaegebeuriD· 1 shared Arkoprovo PauliD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersNeuroscience

Mark KotterORCID

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Author profile →

4 papers

Recent·Most cited

Tau aggregate replication occurs at the pre-synapse of cultured human neurons and increases with application of TNFa

Shekhar Kedia, Emre Fertan, Arkoprovo Paul, Valentina Davì, George Nolan, Koby Baranes, Yunzhao Wu, Jae Eun Kim, Annelies Quaegebeur, Mark Kotter, Edward Avezov, Georg Meisl, David Klenerman

The paper shows TNFα promotes tau aggregation at pre-synapses in human neurons, forming non-fibrillar aggregates that replicate rapidly.

bioRxiv · Jun 3, 2026 · PreprintNeuroscience

imAgeScore, a Cell Painting-Based Predictor of Cellular Age for High-throughput Drug Screening Applications

Eleni Patili, Fabio M. D’Orazio, Jack Brelstaff, Koby Baranes, Rodrigo L. dos Santos, Mark Kotter, Joana M. Tavares

imAgeScore predicts cellular age using Cell Painting features, identifies age-modulating compounds, and validates rejuvenation effects in human fibroblasts.

bioRxiv · Mar 10, 2026 · PreprintCell Biology

Drug treatment alters performance in a neural microphysiological system of information processing

Bradley Watmuff, Forough Habibollahi, Candice Desouza, M. Amin Khajehnejad, Alon Loeffler, Koby Baranes, Noah Poulin, Mark Kotter, Brett J. Kagan

The paper tests anti-seizure drugs on a synthetic neural system and finds carbamazepine improves gameplay metrics, linking glutamatergic inhibition to enhanced performance.

Communications Biology · Jun 17, 2025Peer-reviewedNeuroscience

Circadian clocks in human cerebral organoids

Nina Marie Rzechorzek, Magdalena A. Sutcliffe, Andrei Mihut, Koby Baranes, Nuzli Karam, Daniel J Lloyd-Davies Sanchez, Sew‐Yeu Peak‐Chew, Aiwei Zeng, Noah Poulin, Estere Seinkmane, Muhammad Kaiser Abdul Karim, Christopher M. Proctor, Mark Kotter, Madeline A. Lancaster, Andrew D. Beale

This study demonstrates circadian rhythms in human brain cells and organoids, showing they are temperature-compensated and modulated by drugs and cortisol, with implications for chronobiology and brain health.

bioRxiv · Feb 20, 2024 · PreprintNeuroscience