Priti Kumar

Development of a recombinant adeno-associated virus vector for human T lymphocyte- and natural killer cell-targeted gene therapy

This paper develops a CD7-targeted rAAV vector for efficient gene delivery to human T and NK cells, showing reduced off-target effects and improved transgene expression through genome optimization.

The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC

This study shows that the CD4 mimetic CJF-III-288 enables anti-CoRBS antibodies to mediate ADCC by stabilizing an asymmetric open Env conformation.

Electron tomography visualization of HIV-1 virions trapped by fusion inhibitors to host cells in infected tissues

The paper uses electron tomography to visualize HIV-1 virions trapped by fusion inhibitors in infected tissues, revealing pre-hairpin intermediates linked to host cells.

CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies

The paper shows CD4 downregulation precedes Env expression in HIV-1-infected cells, making them resistant to non-neutralizing antibody-mediated ADCC.

Exploring Single-Cell Data with Deep Multitasking Neural Networks

SAUCIE is a deep neural network that processes large single-cell datasets, performs batch correction, and identifies cluster-based signatures in dengue patient T cells.