Author

Patrick Wanningen

Leiden UniversityORCID 0000-0002-6911-2030Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:virus· 1

Frequent Co-Authors

Adrien DelpaliD· 1 shared Alex MatsudaiD· 1 shared Anna CzarnaiD· 1 shared Colin Robinson· 1 shared Craig D. L. SmithiD· 1 shared Duncan E. ScottiD· 1 shared Edcon ChangiD· 1 shared Eric J. SnijderiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Adrien DelpalORCID

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1 paper

Recent·Most cited

Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase

Irene Georgiou, Colin Robinson, Sean N. O’Byrne, Alex Matsuda, Przemysław Grygier, Craig D. L. Smith, Sandra O’Neill, Shamshad A. Ahmad, Suzanne Norval, John M. Post, G. J. Mirjam Groenewold, Nadya Urakova, Patrick Wanningen, Leanid Kresik, Jacek Plewka, , Ian Hugh Gilbert

The paper develops bi-substrate inhibitors of SARS-CoV-2 nsp14 methyltransferase using structure-guided design, achieving nanomolar potency but limited cellular antiviral activity.

RSC Medicinal Chemistry · Jan 1, 2026Peer-reviewedBiochemistry