Author

Leanid Kresik

Delft University of TechnologyORCID 0000-0002-7739-8358Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Organism:virus· 1

Frequent Co-Authors

Adrien DelpaliD· 1 shared Alex MatsudaiD· 1 shared Anna CzarnaiD· 1 shared Colin Robinson· 1 shared Craig D. L. SmithiD· 1 shared David M. WoodiD· 1 shared Davide ComolettiiD· 1 shared Dimphna H. MeijeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Adrien DelpalORCID

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2 papers

Recent·Most cited

Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase

Irene Georgiou, Colin Robinson, Sean N. O’Byrne, Alex Matsuda, Przemysław Grygier, Craig D. L. Smith, Sandra O’Neill, Shamshad A. Ahmad, Suzanne Norval, John M. Post, G. J. Mirjam Groenewold, Nadya Urakova, Patrick Wanningen, Leanid Kresik, Jacek Plewka, , Ian Hugh Gilbert

The paper develops bi-substrate inhibitors of SARS-CoV-2 nsp14 methyltransferase using structure-guided design, achieving nanomolar potency but limited cellular antiviral activity.

RSC Medicinal Chemistry · Jan 1, 2026Peer-reviewedBiochemistry

The trimeric structures of the extracellular domains of FAM171A1 and FAM171A2 neuronal proteins belong to a novel structural superfamily

Thomas W. Bird, Sepideh Valimehr, David M. Wood, Zachary D. Tillett, Leanid Kresik, Gerd Mittelstädt, Florian De Pol, Dimphna H. Meijer, Renwick C. J. Dobson, Joris de Wit, Eric G. Hanssen, Davide Comoletti

This study determines the trimeric structures of FAM171A1 and FAM171A2 extracellular domains, revealing a novel structural superfamily and their oligomerization properties.

bioRxiv · Sep 18, 2025 · PreprintNeuroscience