Author

Brian J. Smith

National Institutes of HealthORCID 0000-0002-7091-3046Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 9 Organism:mouse· 6 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:non-human primate· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Franziska Karola KaiseriD· 5 shared Reshma Koolaparambil MukeshiD· 5 shared Shane GalloglyiD· 5 shared Chad S. ClancyiD· 4 shared Claude Kwe YindaiD· 4 shared Jonathan E. SchulziD· 4 shared Sarah van ToliD· 4 shared Vincent Jacobus MunsteriD· 4 shared

Activity by Year

2024-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersMicrobiology

Franziska Karola KaiserORCID

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Developing and Characterizing a Murine Model of In Utero Transmission of Ebola Virus

Hanora A. Van Ert, Corey W. Henderson, Brian J. Smith, Paige T. Richards, Ethan Kardin, Emma Eubank, Maryam Fakhimi, Matthew Liebermann, Kelly N. Messingham, Mark Kharim Orcullo Santillan, Mark L. Schultz, Andrea Marzi, Wendy J. Maury

The paper develops a murine model of in utero Ebola virus transmission and shows placental infection and fetal transmission occur within 2-3 days post-infection.

bioRxiv · Aug 5, 2026 · PreprintMicrobiology

Jamaican fruit bats are susceptible to henipaviruses but rapidly control infection

Julianne Bullock, Brown Bulloch, Arthur Wickenhagen, Shane Gallogly, Franziska Karola Kaiser, Jonathan E. Schulz, Trenton Bushmaker, Reshma Koolaparambil Mukesh, Brandi N. Williamson, Kailin Hawes, Anthony McBain, Jessica Prado-Smith, Chad S. Clancy, Brian J. Smith, Julia Rebecca Port, , Sarah van Tol

This study shows Jamaican fruit bats are susceptible to henipaviruses but rapidly control infection following oral exposure.

bioRxiv · Jul 19, 2026 · PreprintMicrobiology

A Single-Dose Bundibugyo Virus Vaccine Protects Macaques Within 3 Days

Kyle Lee O’Donnell, Jil Alexandra Haase, Corey W. Henderson, B. Ryder Gathright, Paige Fletcher, Joseph F. Rhoderick, Chad S. Clancy, Shilpi Jain, César G. Albariño, Brian J. Smith, Andrea Marzi

A single-dose VSV-BDBV vaccine protects macaques from BDBV challenge within 3 days by inducing neutralizing antibodies and Fc effector function.

bioRxiv · Jun 15, 2026 · PreprintMicrobiology

Lower pathogenicity but similar genital shedding of monkeypox virus clade Ib compared to clade Ia in a rodent model

Franziska Karola Kaiser, Shane Gallogly, Reshma Koolaparambil Mukesh, Missiani Ochwoto, Claude Kwe Yinda, Sarah van Tol, Jonathan Schulz, Kailin Hawes, Brown Bulloch, Anthony McBain, Trenton Bushmaker, Atsushi Okumura, Jessica Prado-Smith, Brian J. Smith, Kyle Rosenke, , Vincent Jacobus Munster

bioRxiv · Dec 9, 2025 · PreprintMicrobiology

Highly efficient anogenital transmission of clade Ia mpox virus associated with increased shedding.

Franziska Karola Kaiser, Reshma Koolaparambil Mukesh, Shane Gallogly, Jonathan E. Schulz, Sarah van Tol, Natalie McCarthy, Missiani Ochwoto, Claude Kwe Yinda, Atsushi Okumura, Lara M. Myers, Aaron Carmody, Brian J. Smith, Greg A. Saturday, Carl Shaia, Kyle Rosenke, , Vincent Jacobus Munster

This study investigates mpox virus transmission in prairie dogs, finding that anogenital mucosal routes lead to high shedding and efficient transmission.

bioRxiv · Aug 14, 2025 · PreprintMicrobiology

Increased contact transmission of contemporary Human H5N1 compared to Bovine and Mountain Lion H5N1 in a hamster model

Reshma Koolaparambil Mukesh, Franziska Karola Kaiser, Jonathan E. Schulz, Shane Gallogly, Jessica Prado-Smith, Arthur Wickenhagen, Kathleen Cordova, Brian J. Smith, Chad S. Clancy, Carl Shaia, Greg A. Saturday, Emmie de Wit, Neeltje van Doremalen, Claude Kwe Yinda, Vincent Jacobus Munster

The study compares contact transmissibility of human, bovine, and mountain lion H5N1 isolates in Syrian hamsters, finding human isolate has higher contact transmissibility despite limited overall transmission.

bioRxiv · Jun 23, 2025 · PreprintMicrobiology

Single-dose VSV-Sudan virus vaccine protects from lethal Sudan virus infection within one week: a challenge study in macaques

Paige Fletcher, Kyle Lee O’Donnell, Friederike Feldmann, Joseph F. Rhoderick, Chad S. Clancy, Cecilia A. Prator, Brian J. Smith, Bronwyn M. Gunn, Heinz Feldmann, Andrea Marzi

A single dose of VSV-SUDV vaccine protected macaques from lethal SUDV infection within one week, while VSV-EBOV provided no cross-protection.

bioRxiv · Mar 26, 2025 · PreprintMicrobiology

Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology

Arthur Wickenhagen, Meaghan Flagg, Julia Rebecca Port, Claude Kwe Yinda, Kerry Goldin, Shane Gallogly, Jonathan E. Schulz, Tessa R. Lutterman, Brandi N. Williamson, Franziska Karola Kaiser, Reshma Koolaparambil Mukesh, Sarah van Tol, Brian J. Smith, Neeltje van Doremalen, Colin A. Russell, , Vincent Jacobus Munster

This study evaluates the fitness and pathogenesis of Omicron variants in the upper and lower respiratory tracts, finding increased URT fitness with reduced lung pathology.

Nature Communications · Jan 11, 2025Peer-reviewedMicrobiology

Ixochymostatin, a trypsin inhibitor-like (TIL) protein from Ixodes scapularis, inhibits chymase and impairs vascular permeability

Larissa Almeida Martins, Markus Berger, Jan Kotál, Stephen M. Lu, Lucas Christian de Sousa‐Paula, Brian J. Smith, Yixiang Zhang, John F. Andersen, Lucas Tirloni

This paper identifies ixochymostatin, a TIL protein from Ixodes scapularis, which inhibits chymase and reduces vascular permeability, aiding tick blood feeding.

International Journal of Biological Macromolecules · Nov 22, 2024Peer-reviewedBiochemistry