Matthew J. Vukovich

A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein

The paper identifies a human antibody that neutralizes RSV and hMPV by targeting a novel epitope spanning multiple antigenic sites, showing cross-protection in a mouse model.

Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses

Stabilizing H5 HA mutations enhance neutralizing antibody responses by shifting epitope targeting toward the receptor binding site in vaccinated mice.

Generation of antigen-specific paired chain antibody sequences using large language models

This paper introduces MAGE, a model that generates paired human antibody sequences against specific targets, validated against SARS-CoV-2, H5N1, and RSV-A.

Negative Binomial Mixture Model for Identification of Noise in Antigen-Specificity Predictions by LIBRA-seq

The paper introduces a negative binomial mixture model to denoise LIBRA-seq data, improving antigen binding predictions across multiple donors.