The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

eLife · Sep 1, 2023Peer-reviewedNeuroscience

Improving Polygenic Prediction in Ancestrally Diverse Populations

Yunfeng Ruan, Kuang Lin, Yen‐Chen Anne Feng, Chia‐Yen Chen, Max Lam, Zhenglin Guo, Stanley Global Asia Initiatives, Yong Min Ahn, Kazufumi Akiyama, Makoto Arai, Ji Hyun Baek, Wei J. Chen, Young‐Chul Chung, Gang Feng, Kumiko Fujii, , Tian Ge

This paper introduces PRS-CSx, a method that improves polygenic prediction across ancestrally diverse populations by integrating GWAS summary statistics and sharing genetic effects.

Nature Genetics · May 1, 2022Peer-reviewedGenetic & Genomic Medicine

The cerebellum as a moderator of negative bias of facial expression processing in depressive patients

Anna Nakamura, Yukihito Yomogida, Miho Ota, Junko Matsuo, Ikki Ishida, Shinsuke Hidese, Hiroshi Kunugi

This study identifies a negative bias in facial expression recognition in MDD patients and suggests the cerebellum modulates this bias through altered neural activity.

Journal of Affective Disorders Reports · Dec 15, 2021Peer-reviewedNeuroscience

AUTS2 regulation of synapses for proper synaptic inputs and social communication.

Kei Hori, Kunihiko Yamashiro, Taku Nagai, Wei Shan, Saki F. Egusa, Kazumi Shimaoka, Hiroshi Kuniishi, Masayuki Sekiguchi, Yasuhiro Go, Shoji Tatsumoto, Mitsuyo Yamada, Reika Shiraishi, Kouta Kanno, Satoshi Miyashita, Asami Sakamoto, , Mikio Hoshino

This study shows that AUTS2 regulates excitatory synapse number to maintain E/I balance, and its loss leads to autistic-like behaviors and increased brain excitability.

iScience · May 18, 2020Peer-reviewedNeuroscience