Jim Kaufman

Simplifying principles underlying the highly complex peptide motif of the promiscuous chicken class I molecule, BF2*21:01

The paper identifies simplifying principles governing peptide binding by the promiscuous chicken class I molecule BF2*21:01, revealing patterns that enable broad peptide repertoire while maintaining stable binding.

MHC-I diversity enables rapid adaptation during viral pandemic in wild rabbit populations

The paper shows MHC-I diversity allowed wild rabbits to rapidly adapt to the myxoma virus pandemic through evolutionary shifts in allele frequencies.

A major histocompatibility complex (MHC) class II molecule that binds the same viral pathogen peptide with both nonamer and decamer core sequences for presentation to T cells

The paper identifies a chicken MHC class II molecule that binds the same viral peptide with both nonamer and decamer core sequences, revealing binding plasticity in immune response to MDV.

A single-nucleus census of immune and non-immune cell types for the major immune organ systems of chicken.

The paper presents a single-nucleus atlas of immune and non-immune cell types in chicken immune organs, revealing transcriptomic diversity and intercellular communication in response to bacterial infection.

Genetic control of Campylobacter colonisation in broiler chickens: genomic and transcriptomic characterisation

This study identifies genetic loci and gene expression patterns associated with Campylobacter resistance in broiler chickens, providing insights for breeding programs.

Resources for genome editing in livestock: Cas9-expressing chickens and pigs

This paper generates Cas9-expressing transgenic chickens and pigs for in vivo genome editing, demonstrating their health, fertility, and functionality across multiple tissues and genes.