This study examines how different cannabis THC:CBD compositions affect oligodendrocyte progenitor cells in mice after acute vapor inhalation, finding morphological and mitochondrial changes similar to early differentiation.

bioRxiv · Sep 24, 2026 · PreprintNeuroscience

Sex-Specific Genetic Architecture and Comorbidities of Alcohol Use Behaviors

Laura Vilar‐Ribó, Mariela V. Jennings, Aisha Sallah, Maria Niarchou, Zeal Jinwala, Hayley H. A. Thorpe, Sevim B. Bianchi, J. Wayne Meredith, Kyra L. Feuer, Lydia Rader, Natasia S. Courchesne‐Krak, Jared V. Balbona, Sarah L. Elson, Pierre Fontanillas, Emma C. Johnson, , Sandra Sanchez‐Roige

This study identifies sex-specific genetic loci and correlations for alcohol use behaviors and their comorbidities using genome-wide association studies.

medRxiv · Mar 11, 2026 · PreprintGenetic & Genomic Medicine

Genome-wide association studies of lifetime and frequency cannabis use in 131,895 individuals

Hayley H. A. Thorpe, Pierre Fontanillas, John J. Meredith, Mariela V. Jennings, Renata Basso Cupertino, Shreya Reddy Pakala, Sarah L. Elson, Jibran Younis Khokhar, Lea Karatheodoris Davis, Emma C. Johnson, Abraham A. Palmer, Sandra Sanchez‐Roige

This paper conducts GWAS on cannabis use frequency and lifetime use, identifies genetic loci, and shows genetic correlations with other traits and diseases.

Molecular Psychiatry · Oct 12, 2025Peer-reviewedGenetic & Genomic Medicine

Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking

Emma C. Johnson, Isabelle Austin-Zimmerman, Hayley H. A. Thorpe, Daniel F. Levey, David A. A. Baranger, Sarah M. C. Colbert, Ditte Demontis, Jibran Younis Khokhar, Lea Karatheodoris Davis, Howard J. Edenberg, Marta Di Forti, Sandra Sanchez‐Roige, Joel E. Gelernter, Arpana Agrawal A

This study investigates genetic correlations and causal relationships between schizophrenia, cannabis use disorder, and tobacco smoking across African and European ancestries, identifying pleiotropic loci and convergent genetic effects.

Neuropsychopharmacology · Jun 21, 2024Peer-reviewedGenetic & Genomic Medicine

Genome-Wide Association Studies of Coffee Intake in UK/US Participants of European Ancestry Uncover Gene-Cohort Influences

Hayley H. A. Thorpe, Pierre Fontanillas, Benjamin K. Pham, John J. Meredith, Mariela V. Jennings, Natasia S. Courchesne‐Krak, Laura Vilar‐Ribó, Sevim B. Bianchi, Julian Mutz, Sarah L. Elson, Jibran Younis Khokhar, Abdel Abdellaoui, Lea Karatheodoris Davis, Abraham A. Palmer, Sandra Sanchez‐Roige

This study compares GWAS results of coffee intake from 23andMe and UK Biobank, finding discrepancies in genetic correlations with health traits and highlighting cultural differences in gene-cohort influences.

medRxiv · Sep 9, 2023 · PreprintGenetic & Genomic Medicine

Alcohol and Vapourized Nicotine Co-Exposure During Adolescence Contribute Differentially to Sex-Specific Behavioural Effects in Adulthood

Jessica Ruffolo, Jude A. Frie, Hayley H. A. Thorpe, Malik Asfandyaar Talhat, Jibran Younis Khokhar

This study examines how adolescent exposure to alcohol and vapourized nicotine affects reward and cognition in adult male and female rats, finding sex-specific behavioural differences.

Nicotine & Tobacco Research · Nov 30, 2021Peer-reviewedNeuroscience