Joo‐Hyeon Lee

Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis

This study uses spatial transcriptomics and lineage tracing to show how tumor subclones drive microenvironmental changes that promote metastasis in a mouse model.

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

Red2Flpe-SCON: A Versatile, Multicolor Strategy for Generating Mosaic Conditional Knockout Mice

The paper introduces Red2Flpe-SCON, a multicolor system for generating mosaic conditional knockout mice, and uses it to show Sox2 is not essential for stem cell maintenance but for proliferation and differentiation.

scRNA-Seq-based drug repurposing targeting idiopathic pulmonary fibrosis (IPF)

This study uses scRNA-Seq data to identify drug candidates for repurposing in IPF by matching cell transition signatures to drug perturbation signatures.

Mutational impact and signature of ionizing radiation

The paper investigates the mutational impact of ionizing radiation on normal cells and confirms these signatures in IR-induced cancers.