This study shows that TOMM40 regulates lipid metabolism in hepatocytes through an LXR-dependent pathway, affecting plasma lipid levels and hepatic lipid droplet accumulation.

Molecular Metabolism · Nov 1, 2024Peer-reviewedCell Biology

CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor

Geoffrey A. Smith, Arun Padmanabhan, Bryan Hill-Fung Lau, Akhil Pampana, Li Li, Clara Youngna Lee, Angelo Pelonero, Tomohiro Nishino, Nandhini Sadagopan, Vivian Q. Xia, Rajan Jain, Pradeep Natarajan, Roland S. Wu, Brian L. Black, Deepak Srivastava, , John S. Chorba

A genome-wide CRISPR screen identifies CSDE1 as a key regulator of hepatic LDLR mRNA decay in vivo, making it a promising target for heart disease.

Science Translational Medicine · Sep 14, 2022Peer-reviewedGenomics

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

David Ezra Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Hüttenhain, Robyn M. Kaake, Alicia Richards, Beril Tutuncuoglu, , Natalia Jura

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.

Nature · Apr 30, 2020Peer-reviewedSystems Biology✦ In-depth digest